Development and Validation of a Uplc-Qtof-Ms Method for Blood Analysis of Isomeric Amphetamine-Related Drugs

The identification of isomeric drugs is gaining increasing importance in forensics and doping control. Isomers vary terms safety, effectiveness, regulation, particularly for amphetamine-related (ARDs). This study developed validated a pseudo-isocratic UPLC-qTOF-MS analytical method the Amphetamine-related (ARDs) blood following mixed-mode solid-phase extraction (MMSPE). procedure requires 250 ?L to achieve limit quantification (LOQ) detection (LOD) 20 ng/mL all analytes. In aged animal samples, recoveries 63–90% matrix effects 9–21% were observed. Precision accuracy analytes within 20% 89–118%, respectively. was accordance with Scientific Working Group Forensic Toxicology (SWGTOX) Standard. It has acceptable precision use control forensic toxicology.